Structures available for Coagulation Factor V


All complete FV structural analysis presented within this database uses the previously published 7KVE structure taken from the Protein Data Bank stitched with the AlphaFold FV prediction to fill in the missing B domain from 7KVE. The complete FV structure consists of the A1, A2, B, A3, C1, and C2 domains.

FVa specific analysis uses the 7KXY PDB structure.

Experimental Structures available for Human Coagulation Factor V


 PDB  

 Method  

 Description 

 Resolution 

 Chain 

 Position 

 PDBsum 

1CZS X-RAY CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN COAGULATION FACTOR V: COMPLEX WITH PHENYLMERCURY 1.9 A 2065-2224 >>
1CZT X-RAY CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN COAGULATION FACTOR V 1.8 A 2065-2224 >>
1CZV X-RAY CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN COAGULATION FACTOR V: DIMERIC CRYSTAL FORM 2.4 A/B 2065-2224 >>
3P6Z X-RAY Structural basis of thrombin mediated factor V activation: essential role of the hirudin-like sequence Glu666-Glu672 for processing at the heavy chain-B domain junction 1.7 C/F 665-737 >>
3P70 X-RAY Structural basis of thrombin-mediated factor V activation: essential role of the hirudin-like sequence Glu666-Glu672 for processing at the heavy chain-B domain junction 2.5 I/J 665-737 >>
3S9C X-RAY Russell's viper venom serine proteinase, RVV-V in complex with the fragment (residues 1533-1546) of human factor V 1.8 B 1561-1574 >>
7KVE ELECT Cryo-EM structure of human Factor V at 3.3 Angstrom resolution 3.3 A 29-2224 >>
7KVF ELECT Cryo-EM structure of human Factor V at 3.6 Angstrom resolution 3.6 A 29-2224 >>
7KXY ELECT Cryo-EM structure of human Factor Va at 4.4 Angstrom resolution 4.4 A 29-747 >>
NA PREDICT Coagulation factor V AlphaFold structure prediction NA A 1-2224 >>
Factor X Variant Database