In-Depth Variant Analysis:  c.5492T>C (p.Leu1831Pro)
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Variant Comments & Reference:
haematuria requiring frozen-fresh plasma transfusion; lower VWF activityResidue Information:
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Substitution Analysis:
Structural Implications:
FVa: Leu1831 is a buried residue  (surface accessibility value = 0 ).
Leu1831 is in a region of secondary structure within the FV domains.
The DSSP assignment for this residue is ... E.
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